Hi shizumataka,
A pretty big subject but a couple of opinions:
I think that genetic manipulation in general is a huge ethical issue for humans but there is gradation of level of problem. For example if we can eliminate a genetic disease it is pretty hard to argue against. However that then moves down a continuum of enhancement that risks a real divide between those that can afford it and those that cannot. Some would argue that this is basically true anyway because the chasm between a Mumbai slum dweller and a medium income Australian is already huge and we enhance our lives with technology and medical advances already. Overall I think it is an area where we have to have the moral and ethical debates first and implement the technology second although it may be hard to contain.
In terms of cloning I am very cautious. If we are to clone humans what is the purpose? If it is to provide spare body parts then I am dead against it. The author Richard Morgan writes in his novels of people being able to back themselves up outside of their body and then restore themselves to a spare body if they are injured or killed. In his books he describes the long lived humans that arise from this as Methuselahs and ascribes all sorts of mental health problems to them. His view appearing to be we are not meant to live beyond our normal lifespan and trying to do so causes all sorts of problems.
I am not sure that answers your question but feel free to ask again and get more specific with me if you like
Paul
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