Emergent Futures Tumblelog

This is the Tumblelog of Paul Higgins and Sandy Teagle - Futurists from Melbourne and Brisbane in Australia. Go to Emergent Futures to see more or follow on Twitter at FuturistPaul . If you right click on the pictures, titles or links in these posts you will be able to go to the original story on the web. If you click on comments for each post you can either read what others have said or add your own comment via Disqus. If you click on the date of a post it will take you to a single post view where you can copy the web link if you want to send it to someone else. If you click on the tags it will take you to other stories from Emergent Futures with the same tag.

futurescope:

PopSci: How It Works - A 3-D Printer For Liver Tissue

Step 1: Engineers load one syringe with a bio-ink (A) made up of spheroids that each contain tens of thousands of parenchymal liver cells and a second syringe with a bio-ink (B) containing non-parenchymal liver cells that bolster cellular development and a hydrogel that helps with extrusion.

Step 2: Software on a PC wired to the bioprinter instructs a stepper motor attached to the robotic arm to move and lower the pump head (C) with the second syringe, which begins printing a mold. The mold looks like three hexagons arranged in a honeycomb pattern.

Step 3: A matchbox-size triangulation sensor (D) sitting beside the printing surface tracks the tip of each syringe as it moves along the x-, y-, and z- axes. Based on this precise location data, the software determines where the first syringe should be positioned.

Step 4: The robotic arm lowers the pump head (E) with the first syringe, which fills the honeycomb with parenchymal cells.

Step 5: Engineers remove the well plate­ (F)—which contains up to 24 completed microtissues, each approximately 250 microns thick­—and place it in an incubator. There, the cells continue fusing to form the complex matrix of a liver tissue.

[more]

Posted at 12:00pm.

futurescope:

PopSci: How It Works - A 3-D Printer For Liver Tissue

Step 1: Engineers load one syringe with a bio-ink (A) made up of spheroids that each contain tens of thousands of parenchymal liver cells and a second syringe with a bio-ink (B) containing non-parenchymal liver cells that bolster cellular development and a hydrogel that helps with extrusion.
Step 2: Software on a PC wired to the bioprinter instructs a stepper motor attached to the robotic arm to move and lower the pump head (C) with the second syringe, which begins printing a mold. The mold looks like three hexagons arranged in a honeycomb pattern.
Step 3: A matchbox-size triangulation sensor (D) sitting beside the printing surface tracks the tip of each syringe as it moves along the x-, y-, and z- axes. Based on this precise location data, the software determines where the first syringe should be positioned.
Step 4: The robotic arm lowers the pump head (E) with the first syringe, which fills the honeycomb with parenchymal cells.
Step 5: Engineers remove the well plate­ (F)—which contains up to 24 completed microtissues, each approximately 250 microns thick­—and place it in an incubator. There, the cells continue fusing to form the complex matrix of a liver tissue.

[more]
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Notes: